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Hiroshi Koike Selected Research

Alcian Blue

4/2022Possible Repositioning of an Oral Anti-Osteoporotic Drug, Ipriflavone, for Treatment of Inflammatory Arthritis via Inhibitory Activity of KIAA1199, a Novel Potent Hyaluronidase.
1/2020Forced expression of KIAA1199, a novel hyaluronidase, inhibits tumorigenicity of low-grade chondrosarcoma.

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Hiroshi Koike Research Topics

Disease

14Neoplasms (Cancer)
07/2021 - 06/2003
9Aggressive Fibromatosis (Desmoid)
01/2022 - 08/2017
9Stomach Neoplasms (Stomach Cancer)
04/2021 - 03/2004
8Fibroma (Fibromatosis)
01/2022 - 08/2017
6Neoplasm Metastasis (Metastasis)
07/2021 - 01/2014
5Carcinoma (Carcinomatosis)
11/2018 - 02/2004
3Chondrosarcoma
04/2022 - 01/2018
3Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal)
11/2021 - 01/2019
3Renal Cell Carcinoma (Grawitz Tumor)
09/2017 - 01/2014
3Shock
07/2015 - 05/2004
2Sarcoma (Soft Tissue Sarcoma)
02/2022 - 01/2021
2Pain (Aches)
12/2021 - 04/2020
2Prostatic Neoplasms (Prostate Cancer)
06/2012 - 09/2004
1Osteonecrosis (Kienbock's Disease)
05/2022
1Hip Osteoarthritis (Coxarthrosis)
05/2022
1Arthritis (Polyarthritis)
04/2022
1Experimental Arthritis
04/2022
1Osteosclerosis
12/2021
1Infections
12/2021
1Dysbiosis
11/2021
1Osteosarcoma (Osteogenic Sarcoma)
07/2021
1Necrosis
07/2021
1Lymphoma (Lymphomas)
04/2021
1Obesity
01/2021
1Ileus
03/2020
1Foodborne Diseases
01/2020
1Hyperandrogenism
01/2019
1Abdominal Pain (Pain, Abdominal)
11/2017
1Fibrosis (Cirrhosis)
01/2017
1Human Influenza (Influenza)
10/2016
1Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor)
01/2014
1Brain Neoplasms (Brain Tumor)
01/2014
1Paresis (Hemiparesis)
01/2014
1Calculi (Calculus)
07/2012
1Cystitis
06/2010

Drug/Important Bio-Agent (IBA)

5Cadherins (E-Cadherin)IBA
04/2007 - 02/2004
4Hyaluronic Acid (Hyaluronan)IBA
05/2022 - 01/2018
4Pharmaceutical PreparationsIBA
04/2022 - 01/2018
4CateninsIBA
11/2020 - 08/2017
3Hyaluronoglucosaminidase (Hyaluronidase)FDA Link
04/2022 - 01/2020
3Anti-Bacterial Agents (Antibiotics)IBA
06/2010 - 05/2004
3Tumor Biomarkers (Tumor Markers)IBA
04/2007 - 07/2004
3retinoic acid receptor betaIBA
05/2006 - 09/2004
2Alcian BlueIBA
04/2022 - 01/2020
2Vinblastine (Vinblastine Sulfate)FDA Link
11/2020 - 04/2020
2Methotrexate (Mexate)FDA LinkGeneric
11/2020 - 04/2020
2Proteins (Proteins, Gene)FDA Link
10/2016 - 03/2010
2Sunitinib (Sutent)FDA Link
08/2015 - 01/2014
2beta CateninIBA
12/2008 - 02/2004
2DNA (Deoxyribonucleic Acid)IBA
04/2007 - 07/2004
2Biomarkers (Surrogate Marker)IBA
07/2005 - 07/2004
1ipriflavoneIBA
04/2022
1Auranofin (Ridaura)FDA Link
01/2022
1DenosumabFDA Link
12/2021
1AndrogensIBA
11/2021
1ParaffinIBA
07/2021
1Formaldehyde (Formol)FDA Link
07/2021
1EnzymesIBA
07/2021
1Messenger RNA (mRNA)IBA
07/2021
1Hyaluronan SynthasesIBA
07/2021
1Endocrine DisruptorsIBA
01/2021
1Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA
01/2021
1Therapeutic UsesIBA
09/2020
1cereulideIBA
01/2020
1Meloxicam (Mobic)FDA LinkGeneric
12/2019
1pazopanibFDA Link
10/2019
1AntralIBA
01/2019
1HymecromoneIBA
01/2018
1Analgesics (Analgesic Drugs)IBA
11/2017
1Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA
08/2017
1BGP 15IBA
01/2017
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2017
1ursodoxicoltaurineIBA
01/2017
1CollagenIBA
01/2017
1Nuclear Localization Signals (Nuclear Localization Signal)IBA
10/2016
1Complementary DNA (cDNA)IBA
10/2016
1Hemagglutinins (Hemagglutinin)IBA
10/2016
1Transcription Factors (Transcription Factor)IBA
10/2016
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
01/2014
1Imatinib Mesylate (Gleevec)FDA Link
01/2014
1Silicon Dioxide (Silica)FDA LinkGeneric
07/2012
1SilicatesIBA
07/2012

Therapy/Procedure

5Therapeutics
01/2020 - 06/2010
4Drug Therapy (Chemotherapy)
07/2021 - 04/2004
4Gastrectomy
04/2021 - 03/2004
3Lymph Node Excision (Lymph Node Dissection)
04/2021 - 03/2004
3Metastasectomy
01/2021 - 08/2015
3Lithotripsy (Extracorporeal Shockwave Lithotripsy)
07/2015 - 05/2004
2Surgical Amputation (Amputations)
02/2022 - 12/2021
2Nephrectomy
09/2017 - 08/2015
2Splenectomy
09/2017 - 03/2004
1Molecular Targeted Therapy
01/2022
1Radiofrequency Ablation
01/2021
1Conservative Treatment
04/2020
1Operative Surgical Procedures
03/2020
1Nephroureterectomy
11/2018
1Palliative Care (Palliative Therapy)
09/2017
1Decompression
08/2015
1Drug Tapering
01/2014
1Prostatectomy (Retropubic Prostatectomy)
06/2012